ABSTRACT
This essay draws to the center the idea of the ‘world' in Hegel's philosophy. The impetus for this work is given by the experience of the 2020 Covid pandemic. This is, I suggest, the direct experience of the dialectical nature of the ‘world', the direct experience of the contradiction in the world from which the idea of the ‘end of the world' follows. The essay examines Hegel's new, dialectical cosmology in the aftermath of Kant's criticism thereof. In particular, I appeal to the distinction between Schulbegriff and Weltbegriff of philosophy in order to place Hegel within the cosmological tradition and make sense of the possibly cosmological notion of an end of the world. © 2022, Verifiche. All rights reserved.
ABSTRACT
Introduction - MIS-C is the most relevant complication of SARS-CoV-2 infection and has an incidence of 1 case / 2,200 children and adolescents with previous infection. The clinical picture is characterized by a multiorgan involvement and an insufficiently known response to therapy. Objectives - Retrospective analysis carried out in the Paediatric Department of the Ravenna Hospital from April 2020 to March 2022 of the cases admitted with MIS-C, with description of the presentation characteristics, the differences with respect to Kawasaki disease and the therapeutic strategies adopted also with regard to the clinical response. Results - Thirteen cases diagnosed with MIS-C with an average age of 6 years and four months were hospitalized, 4 cases were of Italian origin, 6 of Balkan and 3 of African. All the cases presented with fever> 39 ° C with severe malaise / irritability, associated with skin rash in 9 cases, conjunctivitis in 7 and cheilitis in 5. The most prominent manifestations of organ involvement were abdominal pain / diarrhoea (N = 9), myocardial dysfunction in the absence of coronary involvement (N = 5), presence of pulmonary thickening (N = 5), painful laterocervical lymphadenitis with reduced neck motility (N = 5), subnephrotic proteinuria (N = 7) and hypertransaminasaemia (N = 8). Two cases with “encephalitic-like” psychomotor slowing, one with important ascites and one with oedema of the para/retropharyngeal tissues were clinically relevant for the severity of the onset. Twelve cases were treated with IVIG and methylprednisolone (2 mg /kg), 4 of them were found to be non-responders and required the use of steroid boluses (4 cases) and anakinra (4 cases), in three of the latter in association with steroid boluses, with rapid and decisive clinical response. Conclusions - The serious clinical manifestations that characterize MIS-C do not concern only cardiac involvement. Therapy with an IL-1 inhibitor, anakinra, must also be envisaged as a possible first-line treatment in case of a particularly severe clinical picture at the onset.
ABSTRACT
Background: Novel SARS-CoV-2 infection has been a severe health problem in Italy since the beginning of March 2020, with around 227,000 confirmed cases on May 18th, 2020. The north-western part of Tuscany has been one of the areas with the highest incidence (342/100,000 inhabitants) and the highest lethality rate (31,2/100,000 inhabitants). The lethality rate was higher in men than women (12.6% vs. 7.4%). People aged 70-79 represented half of this population and the deaths in this subgroup represented 15.9% of all SARS-CoV-2-related deaths. Cancer patients are known to be at higher risk of incidence and complications from SARS-CoV-2. We aimed at analyzing the incidence and the lethality of Sars-CoV-2 in our prostate cancer (PC) patients (pts), in whom hormonal therapy seems to be protective from the first evidences published in the literature. Method(s): We reviewed all the clinical files of PC pts'visits performed from March 1st to April 30th, 2020 in the University Hospital of Pisa. We analyzed the demographic characteristics, the comorbidities, the type of hormonal therapy pts received, the incidence of SARS-CoV-2 and the related lethality rate. Result(s): 132 pts with PC had face-to-face or telemedicine visits in the considered period. The median age was 76 (range 52-91);86 (65.15%) pts were 75 or older. The median number of comorbidites was 2 (range 0-6);112 (84.85%) pts had at least two comorbidities. 115 (87.12%) pts received LHRH analogue in the adjuvant or metastatic setting, 17 (12.88%) pts received LHRH analogue in combination with an anti-androgen. One pt had a confirmed SARS-CoV-2 infection (0.76%), other 2 pts (1.52%) had a clinical and/or radiological suspicion of SARS-CoV2 infection, but no PCR confirmation. One of these three pts (0.76%) died of ARDS (the considered pt had no PCR confirmation of SARS-CoV-2);the patient was 89 years old and had three comorbidities. Conclusion(s): In our population, living in a high-incidence area for SARS-CoV2 infection, though being composed by elderly men with a discrete number of comorbidities, the incidence rate was quite low, as well as the lethality rate, corroborating the data published in the literature. Legal entity responsible for the study: The authors. Funding(s): Has not received any funding. Disclosure: All authors have declared no conflicts of interest.Copyright © 2020
ABSTRACT
Background: Novel SARS-CoV-2 infection has been a severe health problem in Italy since the beginning of March 2020, with around 227,000 confirmed cases on May 18th, 2020. The north-western part of Tuscany has been one of the areas with the highest incidence (342/100,000 inhabitants) and the highest lethality rate (31.2/100,000 inhabitants). People aged 70-79 represented half of this population and the deaths in this subgroup represented 15.9% of all SARS-CoV-2-related deaths. Cancer patients are known to be at higher risk of incidence and complications from SARS-CoV-2. We aimed at analyzing the incidence and the lethality of SARS-CoV-2 in our prostate cancer (PC) patients (pts), in whom hormonal therapy seems to be protective from the first evidences published in the literature. Material (Patients) and Methods: We reviewed all the clinical files of PC pts' visits performed from March 1st to April 30th, 2020 in the University Hospital of Pisa. We analyzed the demographic characteristics, the comorbidities, the type of hormonal therapy pts received, the incidence of SARS-CoV-2 and the related lethality rate. Results: 132 pts with PC had face-to-face or telemedicine visits in the considered period. The median age was 76 (range 52-91), the mean age 75.44. The median number of comorbidites was 2 (range 0-6). 115 (87.12%) pts received LHRH analogue, 17 (12.88%) pts received LHRH analogue in combination with an anti-androgen. One pt had a confirmed SARS-CoV-2 infection (0.76%), other 2 pts (1.52%) had a clinical and/or radiological suspicion of SARS-CoV2 infection, but no PCR confirmation. One of these three pts (0.76%) died of ARDS (the considered pt had no PCR confirmation of SARS-CoV-2). Conclusions: In our population, living in a high-incidence area for SARS-CoV2 infection, though being composed by elderly with a discrete number of comorbidities, the incidence rate was quite low, as well as the lethality rate, corroborating the data published in the literature.